B cell depleting therapy regulates splenic and circulating T follicular helper cells in immune thrombocytopenia

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• 作者：Sylvain Audia^a ; ^b ; ^c ; ^{sylvain.audia@u-bourgogne.fr} ; Marzia Rossato^b ; Malika Trad^a ; Maxime Samson^a ; ^c ; Kim Santegoets^b ; Alexandrine Gautheron^a ; Cornelis Bekker^b ; Olivier Facy^d ; Nicolas Cheynel^d ; Pablo Ortega-Deballon^d ; Mathieu Boulin^e ; Sabine Berthier^c ; Vanessa Leguy-Seguin^c ; Laurent Martin^a ; ^f ; Marion Ciudad^a ; Nona Janikashvili^a ; Philippe Saas^a ; Timothy Radstake^b ; ¹ ; Bernard Bonnotte^a ; ^c ; ¹
• 关键词：Immune thrombocytopenia ; T follicular helper cells ; Rituximab
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：77
• 期：Complete
• 页码：89-95
• 全文大小：1390 K
• 卷排序：77

文摘

B cells are required for TFH maintenance in human spleen. B cell depleting therapy in humans decreases TFH and CXCL13, in the spleen and in the circulation. TFH are not involved in the therapeutic inefficiency of RTX in ITP.