Investigation of potential endocrine disrupting effects of mosquito larvicidal Bacillus thuringiensis israelensis (Bti) formulations
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- 作者：Sibylle Maletza ; 1 ; Marc Wollenwebera ; 1 ; Katharina Kubiaka ; Annett Mü ; llera ; Stefan Schmitza ; Dieter Maierb ; Markus Heckerc ; d ; Henner Hollerta ; e ; f ; g ; Henner.Hollert@bio5.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：17-OHP ; 17-hydroxyprogesterone ; 21-OHP ; 21-hydroxyprogesterone ; ASD ; androstenedione ; Bti ; Bacillus thuringiensis var. israelensis ; COR ; corticosterone ; CPRG ; chlorophenol red-尾-d-galactopyranoside ; DCM ; dichloromethane ; DMSO ; dimethyl sulfoxide ; E2 ; 17ß ; -estradiol ; ED ; endocrine disruptor ; EEQ ; estradiol equivalents ; ER CALUX® ; Estrogen Receptor mediated Chemical Activated LUciferase gene eXpression ; H295R ; H295R Steroidogenesis assay ; LOEC ; lowest observed effect concentration ; LYES
- 刊名：Science of the Total Environment
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：536
- 期：Complete
- 页码：729-738
- 全文大小：952 K
文摘
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Some Bti formulations show significant dose-dependent estrogenic activity in vitro.
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Estrogenicity was found in high concentrations of Vectobac TP and solid formulations.
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There was no clear effect on the steroidogenesis in human H295R cells.
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Bti treated surface water as well as ground water showed no estrogenic activity.
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Our data supports previous studies on the safe use of Bti even in sensitive habitats.