Receptors are affected by selection with each Bacillus thuringiensis israelensis Cry toxin but not with the full Bti mixture in Aedes aegypti
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- 作者：Renaud Stalinski ; Frederic Laporte ; Guillaume Tetreau1 ; Laurence Despré ; s ; Laurence.despres@ujf-grenoble.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALP ; alkaline phosphatase ; APN ; aminopeptidase N ; ABC transporters ; ATP-binding cassette transporter ; Bti ; Bacillus thuringiensis israelensis ; SNP ; Single Nucleotide Polymorphism
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：218-227
- 全文大小：944 K
文摘
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Genes encoding for chitin metabolism are upregulated in all selected strains.
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Protoxin processing is not altered in Cry-selected mosquito larvae.
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Toxin-specific modifications in the transcriptional profiles and in polymorphisms of receptors are selected by Bti Cry toxins.
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Selective sweeps associated with Cry4Aa resistance were detected in 2 ALP and 1 APN genes.