Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata

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• 作者：Tran Thi Hong Hanh ; Dan Thi Thuy Hang ; Chau Van Minh ; Nguyen Tien Dat ; ^{ngtiend@hotmail.com}
• 关键词：Chromolaena odorata ; Asteraceae ; Fatty acid ; NF-¦ÊB ; Nitric oxide
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：4
• 期：10
• 页码：760-763
• 全文大小：287 K

文摘

Objective

To identify inhibitors of nitric oxide production and NF-¦ÊB activity from Chromolaena odorata (C. odorata).

Methods

The compounds isolated from the aerial parts of C. odorata by bioassay-guided fractionation were investigated for their inhibitory effects on the NO production and NF-¦ÊB activity in LPS-stimulated RAW264.7 cells.

Results

Six fatty acids (S)-coriolic acid (1), (S)-coriolic acid methyl ester (2), (S)-15,16-didehydrocoriolic acid (3), (S)-15,16-didehydrocoriolic acid methyl ester (4), linoleamide (5) and linolenamide (6) were isolated. All compounds inhibited the NO production at concentrations consistent with those required for NF-¦ÊB inhibition. Compound 2 was the most active with the IC₅₀ values of 5.22 and 5.73 ¦ÌM. The addition of a double bond in the fatty chain decreased the inhibitory effects while the methyl esterification increased the activities.

Conclusions

The fatty acid components in C. odorata with NF-¦ÊB inhibitory activity could explain the anti-inflammation property of this plant in traditional medicine. This study could also contribute to the better use of C. odorata for human health care.