Analysis of TNF-related apoptosis-inducing ligand and receptors and implications in thymus biology and myasthenia gravis

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• 作者：Irem Kanatli^a ; ^b ; Bahar Akkaya^c ; Hilmi Uysal^d ; Sevim Kahraman^a ; ^b ; Ahter Dilsad Sanlioglu^a ; ^b ; ^{ahter@icloud.com}
• 关键词：Myasthenia Gravis ; Thymoma ; Thymic hyperplasia ; TRAIL ; Medical thymectomy
• 刊名：Neuromuscular Disorders
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：27
• 期：2
• 页码：128-135
• 全文大小：2514 K
• 卷排序：27

文摘

We presented altered TRAIL death receptor expressions in Myasthenia Gravis thymus. DR4 and/or DR5 expressions were elevated in abnormal thymic tissue. Normal or Myasthenia Gravis thymus did not express canonically activated NF-kB. Myasthenia Gravis thymus displayed higher apoptotic index compared to normal thymus. Applicability of TRAIL-mediated thymectomy should be investigated.