Sufficient Immunosuppression with Thymoglobulin Is Essential for a Successful Haplo-Myeloid Bridge in Haploidentical-Cord Blood Transplantation
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- 作者：Caroline A. Lindemans1 ; c.a.lindemans@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author ; Liane C.J. te Boome2 ; 3 ; Rick Admiraal1 ; 3 ; 4 ; 5 ; Els C. Jol-van der Zijde4 ; Anne M. Wensing6 ; A. Birgitta Versluijs1 ; Marc B. Bierings1 ; Jü ; rgen Kuball2 ; 3 ; Jaap J. Boelens1 ; 3
- 关键词：Haplo-cord transplantation ; Engraftment ; Thymoglobulin ; ATG ; Infection
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：21
- 期：10
- 页码：1839-1845
- 全文大小：665 K
文摘
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In successful haploidentical–cord hematopoietic cell transplantation, the haplo forms a myeloid bridge until cord blood engraftment
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Sufficient antithymocyte globulin exposure (area under the curve) after hematopoietic cell transplantation is important for the haplo-myeloid bridge
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Without antithymocyte globulin exposure after hematopoietic cell transplantation, both (early) engraftment and hematopoietic cell transplantation outcome are at risk