Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity

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• 作者：Stefanie Perfahl^a ; Anja Bodtke^a ; Jitka Pracharova^b ; Jana Kasparkova^b ; Viktor Brabec^b ; Juan Cuadrado^c ; Stefan Stü ; rup^c ; Carola Schulzke^d ; Patrick J. Bednarski^a ; ^{bednarsk@uni-greifswald.de}
• 关键词：Platinum complexes ; Tetrazolate ; Cytotoxicity ; Synthesis ; DNA binding ; Cancer cells
• 刊名：Inorganica Chimica Acta
• 出版年：2017
• 出版时间：24 February 2017
• 年：2017
• 卷：456
• 期：Complete
• 页码：86-94
• 全文大小：1032 K
• 卷排序：456

文摘

Transplatin was used to prepare trans-diamminoditetrazolato-Pt(II) derivatives. Oxidation of ditetrazolato-Pt(II) complexes to Pt(IV) derivatives done with H2O2. Pt(II) derivatives do not bind to calf thymus DNA. Pt(IV) derivatives need ascorbate to bind to calf thymus DNA. Pt(IV) derivatives are cytotoxic to cancer cells but the Pt(II) complexes are not.