We presented altered TRAIL death receptor expressions in Myasthenia Gravis thymus. DR4 and/or DR5 expressions were elevated in abnormal thymic tissue. Normal or Myasthenia Gravis thymus did not express canonically activated NF-kB. Myasthenia Gravis thymus displayed higher apoptotic index compared to normal thymus. Applicability of TRAIL-mediated thymectomy should be investigated.