Associations between organohalogen concentrations and transcription of thyroid-related genes in a highly contaminated gull population
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- 作者：Romy Té ; chera ; techer.romy@courrier.uqam.ca" class="auth_mail" title="E-mail the corresponding author ; Magali Houdeb ; magali.houde@canada.ca" class="auth_mail" title="E-mail the corresponding author ; Jonathan Verreaulta ; verreault.jonathan@uqam.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gull ; Organochlorine ; Flame retardant ; Hypothalamic&ndash ; pituitary&ndash ; thyroid axis ; Thyroid hormone ; Gene regulation
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：545-546
- 期：Complete
- 页码：289-298
- 全文大小：760 K
文摘
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Gulls from the Montreal area accumulate high liver concentrations of organohalogens
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Associations between organohalogens and variables of the thyroid axis were examined
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Plasma thyroid hormone levels correlated with liver PCBs and PBDEs
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Transcription of many genes in thyroid gland and brain correlated with PCBs/PBDEs
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Compensatory mechanisms of the thyroid axis may have occured in these gulls