Structure-based design and confirmation of peptide ligands for neuronal polo-like kinase to promote neuroregeneration
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- 作者：He-Li Cao ; Hao Chen ; Yu-Hui Cui ; Heng-Li Tian ; Jiong Chen ; jionggchen@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuronal polo-like kinase ; Self-inhibitory peptide ; Molecular recognition ; Neuroregeneration
- 刊名：Computational Biology and Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：238-244
- 全文大小：1584 K
文摘
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The intramolecular KD–PBD interaction in nPLK is investigated at structural level.
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Two continuous peptide fragments are identified as hot spots at the interaction interface.
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One of the two fragments is potential as self-inhibitory peptide to target nPLK.
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The peptide is structurally optimized to derive several mutants with improved activity.