Baicalin attenuates lipopolysaccharide induced inflammation and apoptosis of cow mammary epithelial cells by regulating NF-κB and HSP72
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- 作者：Wenhao Yang1 ; dongdongjianchi@163.com" class="auth_mail" title="E-mail the corresponding author ; Huatao Li1 ; Xia Cong ; Xin Wang ; Zhongling Jiang ; Qian Zhang ; Xiaonan Qi ; Shansong Gao ; Rongfeng Cao ; Wenru Tian ; wrtian@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Baicalin ; Lipopolysaccharide ; Inflammation ; Apoptosis ; Cow mammary epithelial cells ; NF-κB ; HSP72
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：139-145
- 全文大小：727 K
文摘
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We investigated the impact of baicalin and its mechanism on inflammation response and apoptosis induced by LPS in CMECs.
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Baicalin ameliorates inflammation response and apoptosis of the cell by up-regulating HSP72 and down-regulating NF-κB.
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Our study provided a theoretical basis for use of baicalin to treat or prevent cow mastitis in clinical practice.