Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration
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- 作者：R. Kesavana ; 1 ; S. Chandela ; 1 ; S. Upadhyaya ; 1 ; R. Bendrea ; R. Ganugulab ; U.R. Potunurua ; H. Giria ; G. Sahua ; P. Uday Kumarb ; G. Bhanuprakash Reddyb ; G. Joksicc ; A.K. Beraa ; Madhulika Dixita ; mdixit@iitm.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; Gentiana lutea ; Isovitexin ; Endothelial inflammation ; Smooth muscle cell ; PLC-γ ; ROS
- 刊名：Nutrition, Metabolism and Cardiovascular Diseases
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：26
- 期：4
- 页码：293-301
- 全文大小：1756 K
文摘
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Gentiana lutea root extract exerts anti-atherosclerotic effects in diabetic rats.
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Gentiana lutea root extract prevents endothelial inflammation and smooth muscle cell migration.
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Active principle of Gentiana, isovitexin, blocks TNF-α induced expression of adhesion molecules in endothelial cells.
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Isovitexin attenuates PDGF-BB induced ROS/PLC-γ/[Ca2+]i signaling in smooth muscle cells.