Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia

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• 作者：Sibylle G. Schwab^a ; ^{sibylle.schwab@uk-erlangen.de} ; Agung A.A.A. Kusumawardhani^b ; Nan Dai^c ; ^d ; WenWen Qin^c ; ^d ; Mutiara D.B. Wildenauer^c ; ^d ; Feranindhya Agiananda^b ; Nurmiati Amir^b ; Ronald Antoni^b ; Tiana Arsianti^b ; Asmarahadi Asmarahadi^b ; Hervita Diatri^b ; Prianto Djatmiko^b ; Irmansyah Irmansyah^b ; Siti Khalimah^b ; Irmia Kusumadewi^b ; Profitasari Kusumaningrum^b ; Petrin R. Lukman^b ; Lukman Mustar^b ; Martina W. Nasrun^b ; Safyuni Naswati^b ; Prasetiyawan Prasetiyawan^b ; Gerald M. Semen^b ; Kristiana Siste^b ; Heriani Tobing^b ; Natalia Widiasih^b ; Tjhin Wiguna^b ; Widayanti Dewi Wulandari^b ; Indonesian Schizophrenia Genetics Consortium 1
• 关键词：Zinc finger protein ZNF804A ; Association study ; Replication ; Schizophrenia ; Indonesian population ; Asian ancestral background
• 刊名：Schizophrenia Research
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：147
• 期：1
• 页码：46-52
• 全文大小：491 K

文摘

Background

Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background.

Methods

We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR-RFLP assay for confirmation of rs1344706 genotypes.

Results

We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, OR = 1.155, 95 % , CI 1.025-1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706.

Conclusion

We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.