Increase of p25 associated with cortical neuronal death induced by hypoxia
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- 作者：Tianwen Huanga ; 1 ; huangtianwen2002@163.com" class="auth_mail" title="E-mail the corresponding author ; Lijun Fangb ; 1 ; Zhiying Lina ; En Huangc ; Qinyong Yea
- 关键词：Hypoxia ; p35 ; p25 ; Cdk5 ; Neuronal death
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：932-936
- 全文大小：635 K
文摘
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The cortical neurons at 10 DIV, are susceptible to hypoxia, which has similar pathology in adult patients.
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Our result further confirms the aberrant Cdk5 through conversion of p35 to p25 is involved in this pathology.
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The p25/Cdk5 is a potential target to develop a drug for treatment of hypoxic injury.