A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface
详细信息 查看全文
- 作者：Gagan D. Gupta1 ; 8 ; É ; tienne Coyaud2 ; 8 ; Joã ; o Gonç ; alves1 ; 8 ; Bahareh A. Mojarad1 ; 3 ; 8 ; Yi Liu1 ; 3 ; Qianzhu Wu1 ; 3 ; Ladan Gheiratmand1 ; David Comartin1 ; 3 ; Johnny M. Tkach1 ; Sally W.T. Cheung1 ; Mikhail Bashkurov1 ; Monica Hasegan1 ; James D. Knight1 ; Zhen-Yuan Lin1 ; Markus Schueler6 ; 7 ; Friedhelm Hildebrandt6 ; 7 ; Jason Moffat5 ; Anne-Claude Gingras1 ; 3 ; Brian Raught2 ; 4 ; brian.raught@uhnres.utoronto.ca" class="auth_mail" title="E-mail the corresponding author ; Laurence Pelletier1 ; 3 ; pelletier@lunenfeld.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：163
- 期：6
- 页码：1484-1499
- 全文大小：9278 K
文摘
- •
BioID conducted on 58 centriole, satellite, and ciliary transition zone proteins
- •
Centriole-cilium interface map comprises >1,700 unique components, >7,000 interactions
- •
Microscopy and functional screens confirm new centriole-cilium regulatory modules
- •
Dynamic modulation of interaction landscape observed during ciliogenesis program