- 作者：Hsiu-Ting Tsai ; Ph.D.a ; b ; tsaihsiuting@yahoo.com.tw ; Tsung-Hsien Lee ; M.D. ; Ph.D.c ; d ; Shun-Fa Yang ; Ph.D.d ; Long-Yau Lin ; M.D. ; Sc.D.c ; e ; Yi-Torng Tee ; M.D. ; Ph.D.c ; e ; Po-Hui Wang ; M.D. ; Ph.D.c ; d
- 关键词：E-cadherin ; single nucleotide polymorphism (SNP) ; pelvic inflammatory disease (PID)
- 刊名：Fertility and Sterility
- 出版年：2013
- 出版时间：February, 2013
- 年：2013
- 卷：99
- 期：2
- 页码：490-495
- 全文大小：177 K
Objective
To estimate the expression of plasma soluble E-cadherin and the gene polymorphism in patients with pelvic inflammatory disease (PID).Design
Hospital-based case-control study.
Setting
University hospital.
Patient(s)
Sixty-four women with PID.
Intervention(s)
Blood specimen collection from patients before and after they received treatment.
Main Outcome Measure(s)
Enzyme-linked immunosorbent assay and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma soluble E-cadherin level and E-cadherin polymorphism.
Result(s)
The level of plasma E-cadherin was significantly elevated in patients with PID as compared with that in normal controls; it decreased significantly after treatment when compared with levels noted in the same patients before they received treatment. When the cutoff level of plasma E-cadherin level was set to 20.22 ng/mL on the basis of receiver-operating characteristic curve (ROC), the sensitivity, specificity, and the area under the curve of plasma E-cadherin level for predicting PID were 0.81, 0.80, and 0.835 (95 % confidence interval 0.76-0.90), respectively. The adjusted odds ratio for age, white blood cell count, and C-reactive protein levels was 19.66 (5.48-70.47).
Conclusion(s)
Elevated plasma soluble E-cadherin expression was involved in the pathogenesis of PID and is useful for the diagnosis of PID.