Expression of the MOZ-TIF2 oncoprotein in mice represses senescence
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- 作者：Anne Largeota ; Flor Maria Perez-Campo ; a ; &dagger ; ; f.perezcampo@unican.es" class="auth_mail" title="E-mail the corresponding author ; Elli Marinopouloua ; Michael Lie-a-Linga ; Valerie Kouskoffb ; Georges Lacauda ; georges.lacaud@cruk.manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Experimental Hematology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：44
- 期：4
- 页码：231-237.e4
- 全文大小：2171 K
文摘
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MOZ-TIF2 transformation is associated with inhibition of senescence through repression of the CDKN2A locus.
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MOZ histone acetyltransferase activity of MOZ-TIF2 is required for the inhibition of senescence.
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MOZ-TIF2 acts on the p53 apoptosis-versus-senescence balance.