Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models
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- 作者：Teemu Natunena ; 1 ; Mari Takaloa ; b ; 1 ; Susanna Kemppainenb ; Stina Leskelä ; b ; Mikael Marttinena ; Kaisa M.A. Kurkinena ; Juha-Pekka Pursiheimoc ; Timo Sarajä ; rvia ; Jayashree Viswanathand ; Sami Gabbouja ; Eino Soljed ; Eveliina Tahvanainend ; Tiina Pirttimä ; kib ; Mitja Kurkie ; Jussi Paananena ; Tuomas Rauramaaf ; g ; Pasi Miettinenb ; Petra Mä ; kinena ; Ville Leinonenh ; i ; Hilkka Soininend ; j ; Kari Airennek ; Rudolph E. Tanzil ; m ; Heikki Tanilab ; Annakaisa Haapasalob ; j ; 1 ; annakaisa.haapasalo@uef.fi" class="auth_mail" title="E-mail the corresponding author ; Mikko Hiltunena ; j ; 1 ; mikko.hiltunen@uef.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; Amyloid-β (Aβ) ; Amyloid precursor protein (APP) ; Beta-secretase 1 (BACE1) ; Tau ; Lentivirus ; Human brain ; APdE9 transgenic mice ; Neuroinflammation
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：187-205
- 全文大小：1915 K
文摘
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Ubiquilin-1 expression decreases in relation to tau pathology in human brain.
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BACE1 is upregulated in ubiquilin-1-overexpressing neuron-microglia co-cultures.
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Neuronal viability decreases in ubiquilin-1-overexpressing co-cultures.
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Ubiquilin-1 moderately increases levels and activity of BACE1 in APdE9 mouse hippocampi.
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Ubiquilin-1 overexpression results in stabilization and relocation of BACE1.