Protein Import by the Mitochondrial Presequence Translocase in the Absence of a Membrane Potential
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- 作者：Uma Turakhiya1 ; 2 ; 3 ; Karina von der Malsburg1 ; 10 ; Vicki A.M. Gold4 ; Bernard Guiard5 ; Agnieszka Chacinska6 ; Martin van der Laan1 ; 7 ; 8 ; Raffaele Ieva1 ; 9 ; raffaele.ieva@ibcg.biotoul.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Su e ; subunit e ; Su g ; subunit g ; CCCP ; carbonyl cyanide m-chlorophenylhydrazone ; DHFR ; dihydrofolate reductase
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：27 March 2016
- 年：2016
- 卷：428
- 期：6
- 页码：1041-1052
- 全文大小：1048 K
文摘
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A novel pathway of import for small proteins of the inner mitochondrial membrane has been discovered.
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This pathway is mediated by the TIM23 import machinery and it does not require translocase activation by ∆ ψ in isolated mitochondria.
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Lack of positive charges in the matrix domain of subunit e facilitates precursor import in the absence of ∆ ψ.