Interaction of divalent metal ions with human translocase of inner membrane of mitochondria Tim23
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- 作者：Wei Feng ; Yongqiang Zhang ; Honghua Deng ; Shu Jie Li ; shujieli@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitochondria ; TIM23 complex ; Tim23p ; Presequence ; Divalent metal ions ; Interaction
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：17 June 2016
- 年：2016
- 卷：475
- 期：1
- 页码：76-80
- 全文大小：660 K
文摘
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Tim23p is the central component of TIM23 complex.
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Interaction of Tim23p with presequence is crucial for precursor proteins importing.
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We first found the strong interactions of divalent metal ions with human Tim23IMS.
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The interaction of presequence with Tim23IMS is weakened in presence of Ca2+ ions.
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It implicated that Ca2+ may play an important role in protein import by TIM23 complex.