Pharmacological options to protect the aged heart from ischemia and reperfusion injury by targeting the PKA-BKCa signaling pathway
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- 作者：Andre Heinena ; b ; andre.heinen@uni-duesseldorf.de" class="auth_mail ; Martin Strö ; thoffb ; martin.stroethoff@uni-duesseldorf.de" class="auth_mail ; Anika Schmidtb ; anika.schmidt@uni-duesseldorf.de" class="auth_mail ; Nadine Strackeb ; nadine.stracke@med.uni-duesseldorf.de" class="auth_mail ; Friederike Behmenburgb ; friederike.behmenburg@med.uni-duesseldorf.de" class="auth_mail ; Inge Bauerb ; inge.bauer@med.uni-duesseldorf.de" class="auth_mail ; Markus W. Hollmannc ; m.w.hollmann@amc.uva.nl" class="auth_mail ; Ragnar Huhnb ; ragnar.huhn@med.uni-duesseldorf.de" class="auth_mail
- 关键词：BKCa ; large-conductance calcium-sensitive potassium channel ; NS1619 ; 1 ; 3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one ; PKA ; protein kinase A ; Cx43 ; connexin43 ; TIM23 ; translocase of the inner membrane 23 ; kDa ; cAMP ; cyclic adenosine monophosphate ; PLB ; phospholamban
- 刊名：Experimental Gerontology
- 出版年：August 2014
- 年：2014
- 卷：56
- 期：Complete
- 页码：99-105
- 全文大小：676 K
文摘
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Forskolin induced cardioprotection is age-dependent.
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Activation of BKCa channels is involved in forskolin induced protection.
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The loss of protection in the aged heart is not caused by defects in PKA regulation.
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Targeting of BKCa channels initiates protection of the aged heart.