Identification of tonsillar CD4⁺CD25⁻LAG3⁺ T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue

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• 作者：Shuji Sumitomo^a ; Shinichiro Nakachi^a ; Tomohisa Okamura^a ; ^b ; Yumi Tsuchida^a ; Rika Kato^a ; Hirofumi Shoda^a ; Asayo Furukawa^c ; Nobuo Kitahara^c ; Kenji Kondo^d ; Tatsuya Yamasoba^d ; Kazuhiko Yamamoto^a ; Keishi Fujio^a ; ^{kfujio-tky@umin.ac.jp}
• 关键词：Regulatory T cell ; LAG3 ; IL-10 ; PD-L1
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：75-84
• 全文大小：2885 K
• 卷排序：76

文摘

CD4+CD25−LAG3+ T cells compose a distinct T cell subset in the human tonsil. Tonsillar CD4+CD25−LAG3+ T cells suppress antibody production more efficiently than CD4+CD25+ T cells. Cell contact is important for suppression by tonsillar CD4+CD25−LAG3+ T cells. Tonsillar CD4+CD25−LAG3+ T cells suppress graft-versus-host disease (GVHD) reactions in humanized mice. Tonsillar CD4+CD25−LAG3+ T cells are a subset of naturally occurring IL-10-producing Tregs.