Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells
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- 作者：Timothy N. Perkinsa ; Mieke A. Dentenera ; Frank R. Stassenb ; Gernot G. Rohdea ; Brooke T. Mossmanc ; Emiel F.M. Woutersa ; Niki L. Reynaerta ; n.reynaert@maastrichtuniversity.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACTA2 ; Actin ; alpha ; smooth muscle ; ANGPTL4 ; Angiopoietin-like 4 ; ANOVA ; Analysis of variance ; AXIN ; Axis inhibition protein ; BMP ; Bone morphogenic protein ; BMPR1B ; BMP receptor 1B ; CACNA2D3 ; Calcium channel ; voltage-dependent ; alpha 2/delta subunit 3 ; CCND ; Cyclin-D ; CD44 ; CD44 molecule ; CDKN ; Cyclin-dependent kinase inhibitor ; CLDN1 ; Claudin-1 ; CM ; Conditioned medium ; CON ; Control ; COPD ; Chronic obstructive pulmonary disease ; COX2 ; Cyclooxygenase-2 ; CREB ; Cyclic-AMP response element binding pr
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：61-70
- 全文大小：939 K
文摘
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Pathway analysis reveals silica-induced WNT-signaling in lung epithelial cells.
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Silica-induced canonical WNT-signaling is mediated by autocrine/paracrine signals.
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Crystalline silica decreases non-canonical WNT5A signaling.
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Microarray reveals WNT as a novel complex signaling network in silica-mediated injury.