Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

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• 作者：Sarah K. Kaufman¹ ; ³ ; ⁵ ; David W. Sanders¹ ; ³ ; ⁵ ; Talitha L. Thomas³ ; Allison J. Ruchinskas³ ; Jaime Vaquer-Alicea³ ; Apurwa M. Sharma³ ; ⁴ ; Timothy M. Miller² ; Marc I. Diamond³ ; ⁶ ; ^{marc.diamond@utsouthwestern.edu}
• 关键词：tau ; tauopathy ; prion ; prion-like ; transcellular propagation ; strain ; tau pathology ; seeding activity ; cell model
• 刊名：Neuron
• 出版年：2016
• 出版时间：23 November 2016
• 年：2016
• 卷：92
• 期：4
• 页码：796-812
• 全文大小：8138 K
• 卷排序：92

文摘

Tau forms multiple, unique prion strains with distinct biochemical properties Tau strains induce diverse pathological phenotypes in vitro and in vivo Tau strains target different brain regions and propagate pathology at unique rates We present a framework to understand the diversity of human tauopathies