Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease
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- 作者：Roshni Srivastava1 ; Jiasheng Zhang1 ; Gwang-woong Go1 ; 4 ; Anand Narayanan1 ; Timothy P. Nottoli2 ; Arya Mani1 ; 3 ; arya.mani@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：27 October 2015
- 年：2015
- 卷：13
- 期：4
- 页码：746-759
- 全文大小：7216 K
文摘
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LRP6R611C mice exhibit aortic medial hyperplasia and coronary artery disease
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LRP6R611C mice VSMCs have reduced TCF7L2 expression and are undifferentiated
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Activation of non-canonical Wnt is increased in LRP6R611C mice VSMCs
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Wnt3a normalizes the non-canonical Wnt and TCF7L2 activities and rescues the phenotype