Connected nucleophilic substitution-Claisen rearrangement in flow - Analysis for kilo-lab process solutions with orthogonality
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- 作者：Elnaz Shahbazalia ; Max Spapensa ; Hiroki Kobayashib ; Shinichi Ookawarab ; Timothy Noë ; la ; Volker Hessela ;
- 关键词：Flow chemistry ; Microreactors ; Claisen rearrangement ; Continuous process design
- 刊名：Chemical Engineering Journal
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：281
- 期：Complete
- 页码：144-154
- 全文大小：1207 K
文摘
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Orthogonality analysis for connected flow chemistries of large synthetic value.
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Proposal to overcome hurdles through in-flow separations and a kinetic approach.
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Scale-out process schemes for kilolab operation, further in-flow intensification.