A supported aqueous phase catalyst coating in micro flow Mizoroki-Heck reaction

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• 作者：Stefan C. Stouten ; Qi Wang ; Timothy Noë ; l ; Volker Hessel ; ^{v.hessel@tue.nl}
• 关键词：Mizoroki&ndash ; Heck reaction ; Micro flow chemistry ; Microreactor ; Palladium catalyst ; Supported liquid phase catalyst
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：24 April, 2013
• 年：2013
• 卷：54
• 期：17
• 页码：2194-2198
• 全文大小：665 K

文摘

The application of a supported aqueous phase catalyst (SAPC) coating was investigated for the Mizoroki-Heck reaction in micro flow and favorably compared to the use of an SAPC in a batch system. In batch, an 83 % yield was observed after 4 h at 180 ¡ãC with a catalyst loading of 0.4 mol  % , while in flow a residence time of 2.9 min provided a 21 % yield with only 0.01 mol  % catalyst loading. In batch the SAPC could be re-used twice without any significant loss in yield, but further re-use was prevented due to problematic accumulation of an ammonium salt. In the micro flow system, this problem could be overcome by adding water to the product flow prior to cooling, allowing even more effective use of the catalyst.