A lumpy skin disease virus deficient of an IL-10 gene homologue provides protective immunity against virulent capripoxvirus challenge in sheep and goats
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- 作者：Hani Boshraa ; Thang Truonga ; Charles Nfona ; Timothy R. Bowdenb ; Volker Gerdtsc ; Suresh Tikooc ; d ; Lorne A. Babiuke ; Pravesh Karaf ; Arshad Matherf ; David B. Wallacef ; g ; Shawn Babiuka ; h ; shawn.babiuk@inspection.gc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sheep pox ; Goat pox ; Lumpy skin disease ; Vaccine
- 刊名：Antiviral Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：123
- 期：Complete
- 页码：39-49
- 全文大小：1503 K
文摘
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Generation of a lumpy skin disease virus vector by gene knockout of IL-10 gene homologue.
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This lumpy skin disease virus vector was safe in sheep and goats in a small scale study.
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Both humoral and cell mediated immunity are elicited following a single administration.
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Sheep and goats are protected against sheep and goat pox following vaccination.