APOE 4 polymorphism results in early cognitive deficits in an EAE model
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- 作者：Jiang-long Tu ; Chong-bo Zhao ; Timothy Vollmer ; Stephen Coons ; Hao-jie Lin ; Stephen Marsh ; David M. Treiman ; Jiong Shi
- 关键词：Apolipoprotein E ; Cognition ; EAE ; Multiple sclerosis ; Cholinergic ; Water maze
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2009
- 出版时间：10 July 2009
- 年：2009
- 卷：384
- 期：4
- 页码：466-470
- 全文大小：333 K
文摘
Recent clinical studies have identified an association between APOE 4 and cognitive deficits in patients with multiple sclerosis. We induced experimental autoimmune encephalomyelitis (EAE) in APOE knockout (KO) and human APOE 4 knockin (E4) mice to study the interaction of APOE and neuroinflammation on cognition. After EAE induction, KO and E4 showed significant deficits in spatial learning and recall. Regional decreases in choline acetyltransferase localized to the hippocampus. Induction of EAE in a transgenic APOE animal provides a template from which we can decipher the role APOE has on cognition in the context of neuroinflammation.