Ursolic acid liposomes with chitosan modification: Promising antitumor drug delivery and efficacy

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• 作者：Meili Wang^a ; Tingting Zhao^a ; Yanping Liu^a ; Qianqian Wang^a ; Shanshan Xing^a ; Lei Li^a ; Longgang Wang^a ; Lanxiang Liu^b ; Dawei Gao^a ; ^{dwgao@ysu.edu.cn}
• 关键词：Chitosan ; Ursolic acid ; Liposomes ; pH-responsive release ; Antitumor
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：1231-1240
• 全文大小：1709 K
• 卷排序：71

文摘

The novel chitosan-coated ursolic acid liposomes (CS-UA-L) were successfully prepared. CS-UA-L possessed sensitive pH-response, which could release UA rapidly at pH 5.0 comparing with pH 7.4. CS-UA-L exhibited obvious anti-proliferative effect (76.46%) on HeLa cells than UA and UA-L. CS-UA-L suppressed tumor growth more efficiently than those with UA and UA-L in mice bearing U14 cervical cancer. The CS-UA-L allow for precision treatment of the tumor and potential to reduce the total drug dose and side-effect.