The translational potential of circulating tumour DNA in oncology
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- 作者：K.M. Patela ; b ; D.W.Y. Tsuia ; dana.tsui@cruk.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Circulating nucleic acids ; Cancer ; DNA ; Oncology ; Urine ; Plasma ; Blood ; Next generation sequencing
- 刊名：Clinical Biochemistry
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：48
- 期：15
- 页码：957-961
- 全文大小：290 K
文摘
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Plasma ctDNA analysis allows non-invasive monitoring of tumour response.
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Detecting de novo mutants through ctDNA may offer insights into tumour evolution.
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Detecting ctDNA after radical therapy may improve stratification.
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Mutant cfDNA in other body fluids may increase sensitivity to detect rare mutations.