刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1400-1406
全文大小:3878 K
卷排序:482
文摘
IL-23 promoted mammary tumor growth and pulmonary metastasis. IL-23 enhanced the infiltration of M2 macrophages and neutrophils into IL-23-dominated tumor microenvironment (TME). Immunosuppressing cytokines IL-10, TGF-β and VEGF were detected to rise in IL-23-transduced tumor tissues. IL-23 down regulated the ability of CD8+T and CD4+T cells to infiltrate tumors.