Lipopolysaccharide supports maintaining the stemness of CD133+ hepatoma cells through activation of the NF-κB/HIF-1α pathway
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- 作者：Fo-Bao Laia ; b ; 1 ; Wen-Ting Liua ; 1 ; Ying-Ying Jinga ; 1 ; Guo-Feng Yuc ; Zhi-Peng Hana ; Xue Yanga ; Jian-Xing Zenga ; Hang-Jie Zhanga ; Rong-Yu Shia ; Xiao-Yong Lia ; Xiao-Rong Pana ; Rong Lia ; Qiu-Dong Zhaoa ; Meng-Chao Wud ; Ping Zhange ; Jing-Feng Liub ; drjingfeng@126.com" class="auth_mail" title="E-mail the corresponding author ; Li-Xin Weia ; weilixin_smmu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCC ; hepatocellular carcinoma ; CSCs ; cancer stem cells ; TICs ; tumor initiating cells ; LPS ; lipopolysaccharide ; EMT ; epithelial&ndash ; mesenchymal transition ; FBS ; fetal bovine serum ; 5-Fu ; 5-fluorouracil ; TLR4 ; toll-like receptor 4 ; PAMPs ; pathogen-associated molecular patterns
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：378
- 期：2
- 页码：131-141
- 全文大小：2858 K
文摘
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LPS, an important mediator in liver tumor environment, contributes to the stemness maintenance of CD133+ liver CSCs.
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The results indicate that LPS supports the maintenance of CSCs stemness through signaling of the NF-κB/HIF-1α pathway.
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LPS/NF-κB/HIF-1α signaling system may act as a potential target for future development of effective therapy to treat HCC.