Assessment of mouse cognitive and anxiety-like behaviors and hippocampal inflammation following a repeated and intermittent paradoxical sleep deprivation procedure

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• 作者：Mengmei Yin^a ; Yali Chen^b ; Hui Zheng^b ; Tinglin Pu^b ; Charles Marshall^c ; Ting Wu^a ; ^{wuting80000@gmail.com} ; Ming Xiao^b ; ^{mingx@njmu.edu.cn}
• 关键词：Animal model ; Behavioral test ; Neuroinflammation ; Sleep deprivation
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：321
• 期：Complete
• 页码：69-78
• 全文大小：2480 K
• 卷排序：321

文摘

A mouse model of intermittent and repetitive sleep deprivation has been established. The effects of paradoxical sleep deprivation on various behavioral tasks are examined. Neuroinflmmation and neuronal apoptosis endured for even 3 weeks after deprivation.