Blockade of the spinal BDNF-activated JNK pathway prevents the development of antiretroviral-induced neuropathic pain
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- 作者：Maria Domenica Sanna ; Carla Ghelardini ; Nicoletta Galeotti ; nicoletta.galeotti@unifi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antiretroviral ; Neuropathic pain ; JNK ; BDNF ; Caspase-3
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：543-552
- 全文大小：1589 K
文摘
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Antiretroviral induced mechanical and cold allodynia.
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Antiretroviral activated a BDNF-mediated JNK pathway as early event in neuropathy.
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JNK blockade before antiretroviral treatment prevented pain hypersensitivity.
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JNK blockade may be a prophylactic treatment to improve antiretroviral tolerability.