Investigation for role of tissue factor and blood coagulation system in severe acute pancreatitis and associated liver injury

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• 作者：Zhi-Bing Ou^a ; Chun-Mu Miao^a ; Ming-Xin Ye^a ; Ding-Pei Xing^a ; Kun He^a ; Pei-Zhi Li^a ; Rong-Tao Zhu^b ; Jian-Ping Gong^a ; ^{gongjianping11@126.com}
• 关键词：Severe acute pancreatitis ; Tissue factor ; Blood coagulation system ; Kupffer cells ; Liver injury
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：Complete
• 页码：380-388
• 全文大小：3523 K
• 卷排序：85

文摘

This study aims to investigate the molecular mechanisms underlying the pathogenesis of severe acute pancreatitis (SAP) and SAP-associated liver injury, we performed an association analysis of the functions of tissue factor (TF) and blood coagulation system in both SAP patients and mouse SAP model. Our results showed that serum TF and tissue factor-microparticle (TF-MP) levels were highly up-regulated in both SAP patients and SAP mouse model, which was accompanied by the dysfunction of blood coagulation system. Besides, TF expression was also highly up-regulated in the Kupffer cells (KCs) of SAP mouse model. After inhibiting KCs in SAP mouse model, the amelioration of blood coagulation system functions was associated with the decrease in serum TF and TF-MPs levels, and the reduction of SAP-associated liver injury was associated with the decrease of TF expression in KCs. In conclusion, the dis-regulated TF expression and associated dysfunction of blood coagulation system are critical factors for the pathogenesis of SAP and SAP-associated liver injury. TF may serve as a potential and effective target for treating SAP and SAP-associated liver injury.