1,4-syn-Asymmetric induction in the titanium-mediated aldol reactions of chiral methyl α-silyloxy ketones

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• 作者：Adriana Lorente ; Miquel Pellicena ; Pedro Romea ; Fè ; lix Urpí
• 关键词：Stereoselective reactions ; Acetate aldol reactions ; Titanium enolates ; Chiral ketones
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：10 February 2010
• 年：2010
• 卷：51
• 期：6
• 页码：942-945
• 全文大小：299 K

文摘

Good levels of 1,4-syn asymmetric induction are obtained in the TiCl₄-mediated aldol reaction of methyl α-silyloxy ketones with achiral aldehydes. Such methodology represents a new approach to the substrate-controlled acetate aldol reaction, which can be useful to design more efficient syntheses of natural products.