Stereoselective titanium-mediated aldol reactions of ¦Á-benzyloxy methyl ketones

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• 作者：Miquel Pellicena ; Joan G. Solsona ; Pedro Romea ; ^{pedro.romea@ub.edu} ; Fè ; lix Urpí ; ; ^{felix.urpi@ub.edu}
• 关键词：Stereoselective reactions ; Acetate aldol reactions ; Titanium enolates ; Chiral ketones ; Synthesis of natural products
• 刊名：Tetrahedron
• 出版年：2012
• 出版时间：16 December, 2012
• 年：2012
• 卷：68
• 期：50
• 页码：10338-10350
• 全文大小：679 K

文摘

Good levels of 1,4-anti asymmetric induction are obtained in the TiCl₃(i-PrO)-mediated aldol reaction of chiral ¦Á-benzyloxy methyl ketones with a wide array of aldehydes. This methodology represents a new approach to substrate-controlled acetate aldol reactions capable of providing highly functionalized fragments in a straightforward manner, which may be useful in the design of more efficient syntheses.