Total synthesis of ¦Ã-trifluoromethylated analogs of goniothalamin and their derivatives
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- 作者：Jun-Ling Chen ; Zheng-Wei You ; Feng-Ling Qing
- 关键词：Trifluoromethylated ; Goniothalamin ; ¦Á ; ¦Â-Unsaturated ¦Ä-lactone
- 刊名：Journal of Fluorine Chemistry
- 出版年：2013
- 出版时间：November, 2013
- 年：2013
- 卷：155
- 期：Complete
- 页码：143-150
- 全文大小：889 K
文摘
An efficient method for the construction of chiral ¦Ã-trifluoromethylated ¦Á,¦Â-unsaturated ¦Ä-lactone, a widely existing pharmacophore, has been developed and successfully applied for synthesis of ¦Ã-trifluoromethylated goniothalamins. The key steps included Evans-Aldol reaction of chiral titanium enolate of ¦Á-CF3 imide, Wittig olefination and lactonization. The transformation of ¦Ã-trifluoromethylated ¦Á,¦Â-unsaturated ¦Ä-lactone to a series of trifluoromethylated styryllactones was also investigated.