Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus
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- 作者：Tiziano Donnarumma1 ; George R. Young1 ; 2 ; Julia Merkenschlager1 ; Urszula Eksmond1 ; Nadine Bongard4 ; Stephen L. Nutt5 ; Claude Boyer6 ; Ulf Dittmer4 ; Vu Thuy Khanh Le-Trilling4 ; Mirko Trilling4 ; Wibke Bayer4 ; George Kassiotis1 ; 3 ; 7 ; george.kassiotis@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：cytotoxic CD4 T cells ; retroviral infection ; adenovirus-based vaccination ; single-cell RNA sequencing ; inhibitory receptors ; CD4 T cell differentiation ; antiviral immunity
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：17
- 期：6
- 页码：1571-1583
- 全文大小：3457 K
文摘
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Adenoviruses prime CD4 T cells with CTL potential, but retroviruses do not
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CD4 CTLs are transcriptionally distinguishable from other Th cells
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The CD4 CTL program is the direct opposite of the Tfh program
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CD4 CTLs are restrained by the TCF-1-Bcl6 nexus and by PD-1 and LAG3