Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman
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- 作者：Thomas Elter ; Michal Sieniawski ; Axel Gossmann ; Claudia Wickenhauser ; Ursula Schrö ; der ; Harald Seifert ; Johannes Kuchta ; Jü ; rgen Burhenne ; Klaus-Dieter Riedel ; Gerd Fä ; tkenheuer and Oliver
- 关键词：Rhinocerebral aspergillosis ; Voriconazole level ; Intracerebral abscess
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2006
- 出版时间：September 2006
- 年：2006
- 卷：28
- 期：3
- 页码：262-265
- 全文大小：233 K
文摘
Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90 % . We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient responded successfully to salvage combination treatment with voriconazole and caspofungin. Furthermore, for the first time, voriconazole levels in an intracerebral abscess were measured in this patient undergoing voriconazole oral therapy.