Treatment of visceral leishmaniasis with intravenous pentamidine and oral fluconazole in an HIV-positive patient with chronic renal failure — a case report and brief review of the literature

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• 作者：Jan Rybniker ; Valentin Goede ; Jessica Mertens ; Monika Ortmann ; Wolfgang Kulas ; Matthias Kochanek ; Thomas Benzing ; José ; R. Arribas ; Gerd Fä ; tkenheuer
• 关键词：Visceral leishmaniasis ; HIV ; Fluconazole ; Pentamidine ; Miltefosine ; Renal failure
• 刊名：International Journal of Infectious Diseases
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：14
• 期：6
• 页码：e522-e525
• 全文大小：211 K

文摘

Summary

We report the case of an HIV-positive patient with visceral leishmaniasis and several relapses after treatment with the two first-line anti-leishmanial drugs, liposomal amphotericin B and miltefosine. End-stage renal failure occurred in 2007 when the patient was on long-term treatment with miltefosine. A relapse of leishmaniasis in 2008 was successfully treated with a novel combination regimen of intravenous pentamidine and oral fluconazole. Secondary prophylaxis with fluconazole monotherapy did not prevent parasitological relapse of leishmaniasis.