Suppression of LPS-induced NF-κB activity in macrophages by the synthetic aurone, (Z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2H)-one

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• 作者：Hyo S. Park^a ; ^{hsp2g@mtmail.mtsu.edu} ; David E. Nelson^a ; ^{david.e.nelson@mtsu.edu} ; Zachary E. Taylor^b ; ^{zet2d@mtmail.mtsu.edu} ; James B. Hayes^a ; ^{jhayes2582@gmail.com} ; Kirsten D. Cunningham^b ; ^{kdc7c@mtmail.mtsu.edu} ; Brock A. Arivett^a ; ^{baa2j@mtmail.mtsu.edu} ; Rajarshi Ghosh^a ; ^{rg3j@mtmail.mtsu.edu} ; Larissa C. Wolf^a ; ^{lwolf4@uthsc.edu} ; Kimberley M. Taylor^b ; ^{kmt4i@mtmail.mtsu.edu} ; Mary B. Farone^a ; ^{mary.farone@mtsu.edu} ; Scott T. Handy^b ; ^{scott.handy@mtsu.edu} ; Anthony L Farone^a ; ^{Anthony.farone@mtsu.edu}
• 关键词：Aurone ; NF-κB ; IKK-β ; iNOS ; Anti-inflammatory ; Macrophage
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：116-128
• 全文大小：1914 K
• 卷排序：43

文摘

Aurone 1 inhibits TNFα, IL-1β, and IL-8 expression in LPS-stimulated THP-1 cells. p65 translocation and NF-κB-dependent transcription is blocked by aurone 1 in macrophages. The mechanism involves inhibition of IKKβ phosphorylation and IκBα degradation. Aurone 1 has no significant effect on LPS-induced MAPK phosphorylation. Aurone 1 suppresses iNOS expression and NO production in RAW264.7 macrophages.