The metabolic and pharmacokinetic studies for HM-3 in rats based on LC-Q-TOF/MS and LC-MS/MS combing a convenient biological sample processing method
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- 作者：Guangji Wang1 ; Tai Rao1 ; Yuhao Shao ; Jingcheng Xiao ; Dian Kang ; Boyu Shen ; Huimin Chen ; Xinuo Li ; Zhangpei Zhu ; Xiaoxi Yin ; Yan Liang ; liangyan0679@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HM-3 ; Pharmacokinetics ; Metabolism ; LC-Q-TOF/MS ; LC&ndash ; MS/MS
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：1031
- 期：Complete
- 页码：68-75
- 全文大小：1885 K
文摘
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The metabolites in rat plasma were identified using LC-Q-TOF/MS.
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Built a LC–MS/MS method for the measurement of HM-3 and metabolites.
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Heating at 70 °C could avoid the degradation of HM-3 in fresh blood sample.
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Pharmacokinetics of HM-3 was studied in rats.