Hypothermia attenuates the severity of oxidative stress development in asphyxiated newborns

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• 作者：Hiroki Kakita ; Mohamed Hamed Hussein ; Shin Kato ; Yasumasa Yamada ; Yoshiaki Nagaya ; Hayato Asai ; Tatenobu Goto ; Koichi Ito ; Tokio Sugiura ; Ghada Abdel-Hamid Daoud ; Tetsuya Ito ; Ineko Kato ; Hajime Togari
• 关键词：Oxidative stress ; Total hydroperoxide ; Biological antioxidant potential ; Asphyxia ; Brain hypothermia
• 刊名：Journal of Critical Care
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：27
• 期：5
• 页码：469-473
• 全文大小：215 K

文摘

Purpose

This retrospective case-control study aimed to examine the development of oxidative stress in asphyxiated infants delivered at more than 37 weeks of gestation.

Material and Methods

Thirty-seven neonates were stratified into 3 groups: the first group experienced hypothermia (n = 6); the second received hypothermia cooling cup treatment for 3 days, normothermia (n = 16); and the third was the control group (n = 15).

Serum total hydroperoxide (TH), biological antioxidant potential, and oxidative stress index (OSI) (calculated as TH/biological antioxidant potential) were measured within 3 hours after birth.

Results

Serum TH and OSI levels gradually increased after birth in hypothermia and normothermia cases. At all time points, serum TH and OSI levels were higher in hypothermia and normothermia cases than in control cases. Serum TH and OSI levels were higher in normothermia cases than in hypothermia cases at days 3, 5, and 7.

Conclusion

This study demonstrated that hypothermia attenuated the development of systemic oxidative stress in asphyxiated newborns.