Nocodazole treatment interrupted Brucella abortus invasion in RAW 264.7 cells, and successfully attenuated splenic proliferation with enhanced inflammatory response in mice

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• 作者：Alisha Wehdnesday Bernardo Reyes^a ; ^b ; Huynh Tan Hop^a ; Lauren Togonon Arayan^a ; Tran Xuan Ngoc Huy^a ; Wongi Min^a ; Hu Jang Lee^a ; Hong Hee Chang^c ; Suk Kim^a ; ^c ; ^{kimsuk@gnu.ac.kr}
• 关键词：B. abortus ; Nocodazole ; Macrophages ; F-actin ; MAPKs ; Cytokine
• 刊名：Microbial Pathogenesis
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：87-93
• 全文大小：968 K
• 卷排序：103

文摘

Nocodazole directly inhibited the growth of B. abortus in a dose-dependent manner. Nocodazole reduced bacterial invasion with F-actin polymerization inhibition. Nocodazole inhibited ERK and p38α phosphorylation after bacterial infection. Nocodazole treatment increased cytokines production and inhibited bacterial proliferation in the spleens. Nocodazole can be useful for therapeutic application in animal brucellosis.