Antinociceptive Effect of d-Aspartic Acid in Mice

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• 作者：Onat ; F. ; Toker ; F. ; Aslan ; N. ; Oktay ; S. ; Berkman ; K.
• 关键词：Aspartic acid ; Analgesia ; Morphine ; Naloxone
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：1995
• 出版时间：August, 1995
• 年：1995
• 卷：51
• 期：4
• 页码：715-719
• 全文大小：367 K

文摘

The effects of d- and l-aspartic acids on the nociceptive tail flick reflex in mice were investigated. d-Aspartic acid (115-230 mg/kg, IP) was found to increase tail flick latency significantly. Naloxone (0.1 mg/kg) abolished the analgesic effect of d-aspartic acid (115 mg/kg). Morphine and d-aspartic acid, when combined at their nonanalgesic doses, led to significant analgesia. It may be concluded that the opioid system is involved in the antinociceptive effect of d-aspartic acid. Both morphine and d-aspartic acid were previously reported to inhibitl -aspartic acid production via blockade of l-asparaginase. l-Aspartic acid, which was ineffective alone, significantly inhibited the antinociceptive effects of both d-aspartic acid and morphine.