Antagonism of Detomidine-Induced Sedation, Analgesia, Clinicophysiological, and Hematobiochemical Effects in Donkeys Using IV Tolazoline or Atipamezole

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• 作者：Mahmoud Hussein El-Kammar ; MSc ; PhD^a ; ^{m_elkammar2010@yahoo.com" class="auth_mail} ; Shereen Basunei Gad ; MSc ; PhD^b
• 关键词：Antagonism ; Detomidine ; Tolazoline ; Atipamezole ; Hematobiochemical effect ; Donkey
• 刊名：Journal of Equine Veterinary Science
• 出版年：June 2014
• 年：2014
• 卷：34
• 期：6
• 页码：784-792
• 全文大小：489 K

文摘

The present study aimed to investigate and evaluate the reversal of sedation, analgesia, ataxia, clinicophysiological findings, and hematobiochemical effects of detomidine by subsequent IV administration of tolazoline or atipamezole to improve safety and utility of detomidine in donkeys. Six mature donkeys weighing 250–300 kg and aged 4–6 years were used on three separate occasions. Each donkey received the following three treatments at the rate of one treatment per week in a randomized crossover study. The first group received 0.04 mg/kg bwt detomidine. The second group received 0.04 mg/kg bwt detomidine followed by 4.0 mg/kg bwt tolazoline. The third group received 0.04 mg/kg bwt detomidine followed by 0.4 mg/kg bwt atipamezole. Sedation, analgesia, ataxia, pulse rate, respiratory rate, and rectal temperature were recorded at 5 minutes before, then at 5, 15, 30, 60, and 90 minutes after injections. Red blood cell and white blood cell counts, Packed cell volume (%), hemoglobin, total protein, cholesterol, glucose, urea, aspartate amino transferase, alanine amino transferase, and gamma glutamyl transferase values were determined. Detomidine induced deep sedation, complete analgesia, and significant ataxia. Pulse and respiratory rates were decreased from the base line values, although rectal temperature was within the baseline value. The alterations in hematological and hematobiochemical parameters were mild and transient.