Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats

详细信息    查看全文

• 作者：Shereen M. Hamza^a ; ¹ ; Miranda M. Sung^a ; ¹ ; Fei Gao^a ; Carrie-Lynn M. Soltys^a ; Nancy P. Smith^b ; Patrick E. MacDonald^b ; ^c ; Peter E. Light^b ; ^c ; Jason R.B. Dyck^a ; ^b ; ^c ; ^{jason.dyck@ualberta.ca}
• 关键词：Glucose intolerance ; Insulin infusion ; Type 2 diabetes ; Skeletal muscle ; Liver ; p-Akt
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：313-322
• 全文大小：1013 K
• 卷排序：1861

文摘

Chronic insulin exposure actively contributes to development of glucose intolerance. Short-term insulin treatment of obese rats dramatically improves glucose tolerance. Endogenous insulin response significantly improved by short-term insulin treatment. Increased phosphorylation Akt in liver and skeletal muscle