The role of orexin type-1 receptors in the development of morphine tolerance in locus coeruleus neurons: An electrophysiological perspective
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- 作者：Hakime Abdollahi1 ; Masoumeh Ghaemi-Jandabi1 ; Hossein Azizi ; azizih@modares.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Saeed Semnanian
- 关键词：Orexin ; SB-334867 ; Morphine tolerance ; Extracellular in vivo single unit recording ; LC neurons
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1646
- 期：Complete
- 页码：91-97
- 全文大小：1001 K
文摘
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Morphine injection for 6 days led to development of morphine tolerance in LC.
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Development of morphine tolerance in LC neurons was shown by single unit recording.
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OX1R blockade prevented the development of morphine tolerance in LC neurons.